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KMID : 1040420220260010011
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Childhood Kidney Diseases
2022 Volume.26 No. 1 p.11 ~ p.17
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BK polyomavirus-associated nephropathy
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Ahn Yo-Han
Kang Hee-Gyung
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Abstract
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BK polyomavirus (BKPyV) is a ubiquitous virus residing in the kidney tubules and is clinically significant only in immunocompromised patients. In clinical practice, BKPyV is a causative pathogen of BKPyV-associated nephropathy (BKVAN) in kidney allograft recipients or hemorrhagic cystitis of hematopoietic stem cell transplant recipients. Currently, there is no effective treatment for BKVAN; therefore, careful monitoring and prudent modification of immunosuppression are necessary to prevent BKVAN. In this article, the epidemiology, pathophysiology, and current management strategies for BKVAN are reviewed.
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KEYWORD
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BK virus, Immunosuppression therapy, Kidney transplantation
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